NServiceBus version 8.x
Requires .NET 6 (or higher) or .NET Framework Version 4.7.2 (or higher)
NServiceBus version 7.x
Requires .NET Core 2.0 (or higher) or .NET Framework Version 4.5.2 (or higher)
NServiceBus version 6.x
Requires .NET Framework Version 4.5.2 (or higher)
NServiceBus version 5.x
Requires .NET Framework Version 4.5 (or higher)
NServiceBus versions 3.x and 4.x
Requires .NET Framework Version 4.0 (or higher)
Compatibility
NServiceBus targets a specific version of .NET but that does not mean user code must be targeting the same version. This only indicates the minimum required .NET version. The actual framework used at runtime is determined by the application.